ODCs

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1 OMIM reference -
1 associated gene
3 signs/symptoms

PROTEIN INTERACTIONS: 1

2 OMIM references -
2 associated genes
No signs/symptoms info

Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency

Hypohidrotic ectodermal dysplasia with immunodeficiency

IRAK4	(UniProt - OMIM)		IKBKG	(UniProt - OMIM)
			NFKBIA	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	IRAK4	(0.63)	IKBKG

Citations in the biomedical literature:

Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency		Hypohidrotic ectodermal dysplasia with immunodeficiency
	Synonym(s): - IRAK4 deficiency		Synonym(s): - Anhidrotic ectodermal dysplasia with immunodeficiency - EDA-ID - HED-ID

	Classification (Orphanet): - Rare genetic disease - Rare immune disease		Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare genetic disease - Rare immune disease - Rare skin disease

	Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -		Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: any age Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: child / adolescent Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - No MeSH references		External references: 2 OMIM references - No MeSH references

Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency
	Very frequent - Anomalies of the lymphatic system - Immunodeficiency / increased susceptibility to infections / recurrent infections - Polynuclear cells / neutrophils anomalies / neutropenia
Hypohidrotic ectodermal dysplasia with immunodeficiency
(no data available)